Life and death as a T lymphocyte: from immune protection to HIV pathogenesis

Journal of Biology

Table 1 Cellular dynamics in OX40-DTA mouse model [1]

*Percentage decrease or increase in cell population numbers compared with normal controls. ^†Percentage of cell population marked for DTA-mediated deletion by the yellow fluorescent protein marker (YFP). ^‡Determined by loss of BrdU-labeled cells, which might also be influenced by dilution of label following proliferation. ND, not done; ≈, approximately equal to normal controls; ↑, increased compared with normal controls; ^§The increase in BrdU labeling was too low to be determined. The method by which cell turnover was assessed is indicated: BrdU, bromodeoxyuridine, is incorporated into the DNA of proliferating cells upon administration to mice; CFSE, carboxyfluorescein succinimidyl ester, is diluted out from adoptively transferred CFSE-labeled cells with each successive division; Ki67, a protein that is expressed in the nucleus of recently divided cells.